منابع مشابه
Induction of microsomal enzyme synthesis by polycyclic aromatic hydrocarbons of different molecular sizes.
The administration of various polycyclic aromatic hydrocarbons to rats markedly increases the activity of several liver enzyme systems that metabolize certain drugs and other foreign compounds (14). The enzymes which respond to hydrocarbon administration belong to a group of microsomal enzymes that require reduced triphosphopyridine nucleotide for activity. Preliminary observations have suggest...
متن کاملThe liver microsomal hydroxylation enzyme system. Induction and properties of the functional components.
Enzymology of the Liver Frontiers of Gastrointestinal Research Vol. 2 Series Editor: LEO VAN DER RBIS, San Francisco, Calif. Editorial Board: R. LAMBERT, Lyon; S. LORBER, Philadelphia, Pa.; D. W. PIPER, Crows Nest, N.S.W.; H. SHIRAKABE, Tokyo; K.B. TAYLOR, Palo Alto, Calif.; N. ZLLNER, Munich S. Karger Basel' Mnchen . Paris' London' New York' Sydney Enzymology of the Liver Editor: LEO VAN DER R...
متن کاملInhibition of AFB1-induced liver cancer and induction of increased microsomal enzyme activity by dietary constituents.
A long-term study, using male Wistar rats, was initiated to determine whether the effects of dietary constituents on AFB1-induced liver cancer could be associated with altered microsomal enzyme activity. They were maintained on mice pellets mixed with specific dietary constituents for 7 days and then given a single carcinogenic dose of AFB1 (500 micrograms/rat). After three months, the dietary ...
متن کاملSubstrate-inducible microsomal aryl hydroxylase in mammalian cell culture. II. Cellular responses during enzyme induction.
Aryl hydroxylase, derived from hamster fetus cells grown in culture, is an inducible microsomal enzyme system which requires NADPH and molecular oxygen. The addition of benz[u]anthracene or other polycyclic hydrocarbons to the culture medium causes significant increases in the amount of hydroxylase activity: after a lag period of 35 min, the level of hydroxylase activity increases linearly for ...
متن کاملHepatic enzyme induction: histopathology.
Hepatic enzyme induction is generally an adaptive response associated with increases in liver weight, induction of gene expression, and morphological changes in hepatocytes. The additive growth and functional demands that initiated the response to hepatic enzyme induction cover a wide range of stimuli including pregnancy and lactation, hormonal fluctuations, dietary constituents, infections ass...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2000
ISSN: 1096-0929
DOI: 10.1093/toxsci/55.2.233